DATF - The Database of Arabidopsis Transcription Factor
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  • WRKY Family Introduction
  • This family has no structure information!
  • Binding Site of This Family
  • Download Sequences of This Family
          Genomic sequence       cds sequence       protein sequence
  • Multi-alignment and Phylogenetic Tree for DNA binding domain   
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    • List of WRKY family(Total: 72 Loci; 84 Gene Models):

    Page: 1 2 3 list all   (30 Loci a page)
    LocusGene ModelsDescription
    AT1G13960AT1G13960.1 AT1G13960.2 Symbol: WRKY4 | WRKY family transcription factor, similar to WKRY DNA-binding protein GB:AAD17441 | chr1:4776460-4779347 FORWARD | Aliases: F16A14.18
    AT1G18860AT1G18860.1 Symbol: WRKY61 | WRKY family transcription factor, contains Pfam profile: PF03106 WRKY DNA -binding domain | chr1:6509485-6511200 FORWARD | Aliases: ATWRKY61, F6A14.5, F6A14_5, WRKY61
    AT1G29280AT1G29280.1 Symbol: WRKY65 | WRKY family transcription factor, similar to DNA binding protein WRKY3 GB:U56834 GI:1432055 from (Petroselinum crispum) | chr1:10236575-10237453 FORWARD | Aliases: ATWRKY65, F28N24.4, F28N24_4, WRKY65
    AT1G29860AT1G29860.1 Symbol: WRKY71 | WRKY family transcription factor, similar to DNA-binding protein 2 GI:4322940 from (Nicotiana tabacum) | chr1:10454466-10455769 FORWARD | Aliases: ATWRKY71, F1N18.10, F1N18_10, WRKY71
    AT1G30650AT1G30650.1 Symbol: WRKY14 | WRKY family transcription factor, contains Pfam profile: PF03106 WRKY DNA -binding domain | chr1:10868285-10871279 FORWARD | Aliases: AR411, ATWRKY14, T5I8.10, T5I8_10, WRKY14
    AT1G55600AT1G55600.1 Symbol: WRKY10 | WRKY family transcription factor, similar to SPF1 protein GI:484261 from (Ipomoea batatas); contains Pfam profile: PF03106 WRKY DNA -binding domain | chr1:20777715-20779959 REVERSE | Aliases: ATWRKY10, F20N2.3, WRKY10
    AT1G62300AT1G62300.1 Symbol: WRKY6 | WRKY family transcription factor, similar to putative DNA-binding protein GI:7268215 from (Arabidopsis thaliana) | chr1:23020348-23022944 REVERSE | Aliases: F19K23.22, F19K23_22
    AT1G64000AT1G64000.1 Symbol: WRKY56 | WRKY family transcription factor, similar to WRKY DNA binding protein GB:CAB97004 from (Solanum tuberosum) | chr1:23750967-23752716 FORWARD | Aliases: ATWRKY56, F22C12.23, F22C12_23, WRKY56
    AT1G66550AT1G66550.1 Symbol: WRKY67 | WRKY family transcription factor, similar to DNA-binding protein 3 (Nicotiana tabacum) GI:7406995 | chr1:24832200-24833252 FORWARD | Aliases: ATWRKY67, F28G11.3, F28G11_3, WRKY67
    AT1G66560AT1G66560.1 Symbol: WRKY64 | WRKY family transcription factor | chr1:24837242-24838294 FORWARD | Aliases: ATWRKY64, F28G11.2, F28G11_2, WRKY64
    AT1G66600AT1G66600.1 Symbol: WRKY63 | WRKY family transcription factor, contains Pfam profile: PF03106 WRKY DNA -binding domain | chr1:24852069-24852998 FORWARD | Aliases: ATWRKY63, T12I7.5, T12I7_5, WRKY63
    AT1G68150AT1G68150.1 Symbol: WRKY9 | WRKY family transcription factor, similar to DNA-binding protein ABF2 GI:1159879 from (Avena fatua) | chr1:25547633-25549380 FORWARD | Aliases: ATWRKY9, T22E19.22, T22E19_22, WRKY9
    AT1G69310AT1G69310.1 AT1G69310.2 Symbol: WRKY57 | WRKY family transcription factor, contains Pfam profile: PF03106 WRKY DNA -binding domain | chr1:26058350-26061768 REVERSE | Aliases: ATWRKY57, F23O10.11, F23O10_11, WRKY57
    AT1G69810AT1G69810.1 Symbol: WRKY36 | WRKY family transcription factor | chr1:26280901-26282779 REVERSE | Aliases: ATWRKY36, T17F3.16, T17F3_16, WRKY36
    AT1G80590AT1G80590.1 Symbol: WRKY66 | WRKY family transcription factor, similar to zinc finger transcription factor WRKY1 GB:AAF23898 from (Oryza sativa) | chr1:30301102-30302048 REVERSE | Aliases: ATWRKY66, T21F11.8, T21F11_8, WRKY66
    AT1G80840AT1G80840.1 Symbol: WRKY40 | WRKY family transcription factor, similar to WRKY transcription factor GB:BAA87058 GI:6472585 from (Nicotiana tabacum) | chr1:30388584-30390388 FORWARD | Aliases: ATWRKY40, F23A5.19, F23A5_19, WRKY40
    AT2G03340AT2G03340.1 Symbol: WRKY3 | WRKY family transcription factor, contains Pfam profile: PF03106 WRKY DNA -binding domain | chr2:1014347-1017012 REVERSE | Aliases: T4M8.23, T4M8_23
    AT2G04880AT2G04880.1 AT2G04880.2 Symbol: ZAP1 | WRKY family transcription factor (ZAP1), identical to ZAP1 GI:1064883 from (Arabidopsis thaliana); contains Pfam profile: PF03106 WRKY DNA -binding domain | chr2:1717890-1720971 FORWARD | Aliases: ATWRKY1, F1O13.1, F1O13_1, WRKY1, ZAP1
    AT2G21900AT2G21900.1 Symbol: WRKY59 | WRKY family transcription factor, contains Pfam profile: PF03106 WRKY DNA -binding domain | chr2:9341229-9343302 REVERSE | Aliases: ATWRKY59, F7D8.22, F7D8_22, WRKY59
    AT2G23320AT2G23320.1 Symbol: WRKY15 | WRKY family transcription factor, identical to WRKY DNA-binding protein 15 GI:13506742 from (Arabidopsis thaliana) | chr2:9932013-9933452 FORWARD | Aliases: T20D16.5, T20D16_5
    AT2G24570AT2G24570.1 Symbol: WRKY17 | WRKY family transcription factor, identical to WRKY transcription factor 17 GI:15991743 from (Arabidopsis thaliana) | chr2:10444477-10446377 REVERSE | Aliases: ATWRKY17, F25P17.13, F25P17_13, WRKY17
    AT2G25000AT2G25000.1 Symbol: WRKY60 | WRKY family transcription factor, contains Pfam profile: PF03106 WRKY DNA -binding domain | chr2:10636829-10638485 FORWARD | Aliases: ATWRKY60, F27C12.8, F27C12_8, WRKY60
    AT2G30250AT2G30250.1 Symbol: WRKY25 | WRKY family transcription factor | chr2:12910314-12912275 REVERSE | Aliases: ATWRKY25, T9D9.6, T9D9_6, WRKY25
    AT2G30590AT2G30590.1 Symbol: WRKY21 | WRKY family transcription factor | chr2:13040553-13042670 FORWARD | Aliases: T6B20.6, T6B20_6
    AT2G34830AT2G34830.1 Symbol: WRKY35 | WRKY family transcription factor | chr2:14700835-14703457 REVERSE | Aliases: ATWRKY35, F19I3.6, F19I3_6, WRKY35
    AT2G37260AT2G37260.1 Symbol: TTG2 | WRKY family transcription factor (TTG2), contains Pfam profile: PF03106 WRKY DNA -binding domain | chr2:15652486-15654007 FORWARD | Aliases: ATWRKY44, F3G5.5, F3G5_5, TRANSPARENT TESTA GLABRA 2, WRKY44
    AT2G38470AT2G38470.1 Symbol: WRKY33 | WRKY family transcription factor, contains Pfam profile: PF03106 WRKY DNA -binding domain; | chr2:16115537-16117844 FORWARD | Aliases: ATWRKY33, T19C21.4, T19C21_4, WRKY33
    AT2G40740AT2G40740.1 Symbol: WRKY55 | WRKY family transcription factor, contains Pfam profile: PF03106 WRKY DNA -binding domain | chr2:17004255-17006354 FORWARD | Aliases: ATWRKY55, T7D17.8, T7D17_8
    AT2G40750AT2G40750.1 Symbol: WRKY54 | WRKY family transcription factor, contains Pfam profile: PF03106 WRKY DNA -binding domain | chr2:17007532-17009546 REVERSE | Aliases: ATWRKY54, T7D17.7, T7D17_7, WRKY54
    AT2G44745AT2G44745.1 Symbol: None | WRKY family transcription factor, contains Pfam profile: PF03106 WRKY DNA -binding domain | chr2:18454348-18456084 REVERSE | Aliases: None
    Page: 1 2 3 list all

    WRKY Family Introduction

    WRKY family members appear to be involved in the regulation of various physiological programs that are unique to plants, including pathogen defense, senescence and trichome development. In spite of the strong conservation of their DNA-binding domain, the overall structures of WRKY proteins are highly divergent and can be categorized into distinct groups, which might reflect their different functions.

    The WRKY domain is defined by the conserved amino acid sequence WRKYGQK at its N-terminal end, together with a novel zinc-finger-like motif. Because of the clear binding preference of all characterized WRKY proteins for the same DNA motif, it has been assumed that the WRKY domain, as their only conserved structural feature, constitutes a DNA-binding domain. Indeed, it has recently been shown that an isolated WRKY domain has sequence-specific DNA-binding activity. The divalent metal chelators 1,10-o-phenanthroline and EDTA abolish in vitro DNA binding, which is taken as strong support for a zinc-finger structure within the WRKY domain. However, it has not yet been proven that zinc is actually complexed in the WRKY domain. In addition, nothing is known about the function of the WRKYGQK heptapeptide stretch, the hallmark of this superfamily.

    All known WRKY proteins contain either one or two WRKY domains. They can be classified on the basis of both the number of WRKY domains and the features of their zinc-finger-like motif. WRKY proteins with two WRKY domains belong to group I, whereas most proteins with one WRKY domain belong to group II . Generally, the WRKY domains of group I and group II members have the same type of finger motif, whose pattern of potential zinc ligands (C每X4每5每C每X22每23每H每X1每H) is unique among all described zinc-finger-like motifs. The single finger motif of a small subset of WRKY proteins is distinct from that of group I and II members. Instead of a C2每H2 pattern, their WRKY domains contain a C2每HC motif (C每X7每C每X23每H每X1每C). Owing to this distinction, they were recently assigned to the newly defined group III. Nevertheless, experimental evidence has shown that members of all three groups bind sequence specifically to various W box elements.

    Eulgem T, Rushton PJ, Robatzek S, Somssich IE.
    The WRKY superfamily of plant transcription factors
    Trends Plant Sci. 2000 May;5(5):199-206.
    PMID: 10785665

    WRKY Family Binding Site

    FamilySubfamily or DomainCis-element nameBinding siteReference
    WRKY  w-box(T)(T)TGAC[C/T]Plant Mol. Biol. 29 691-702
    WRKY  T03722 

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    last updated:2006-07-20