DATF - The Database of Arabidopsis Transcription Factor
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  • HSF Family Introduction
  • HSF Family Strucutre Information
  • Binding Site of This Family
  • Download Sequences of This Family
          Genomic sequence       cds sequence       protein sequence
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    • List of HSF family(Total: 23 Loci; 24 Gene Models):

    LocusGene ModelsDescription
    AT1G32330AT1G32330.1 Symbol: ATHSFA1D | heat shock transcription factor family protein, contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr1:11656966-11660356 REVERSE | Aliases: F27G20.6, HSFA1D
    AT1G46264AT1G46264.1 Symbol: AT HSFB4 | heat shock transcription factor family protein, contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr1:17227282-17228720 FORWARD | Aliases: F2G19.8, F2G19_8, HSFB4
    AT1G67970AT1G67970.1 Symbol: AT HSFA8 | heat shock factor protein, putative (HSF5) / heat shock transcription factor, putative (HSTF5), identical to heat shock transcription factor 5 (HSF5) SP:Q9S7U5 from (Arabidopsis thaliana); contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr1:25488362-25490125 REVERSE | Aliases: HSFA8, T23K23.18, T23K23_18
    AT1G77570AT1G77570.1 Symbol: None | similar to heat shock transcription factor family protein [Arabidopsis thaliana] (TAIR:At4g13980.1); similar to heat shock factor protein hsf8-related [Glycine max] (GB:AAS15800.1); contains InterPro domain Heat shock factor (HSF)-type DNA-binding domain (InterPro:IPR000232); contains InterPro domain HSF/ETS DNA-binding (InterPro:IPR002341) | chr1:29148244-29148897 FORWARD | Aliases: T5M16.16, T5M16_16
    AT2G26150AT2G26150.1 Symbol: ATHSFA2 | heat shock transcription factor family protein, contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr2:11142760-11144474 FORWARD | Aliases: HSFA2, T19L18.4, T19L18_4
    AT2G41690AT2G41690.1 Symbol: AT HSFB3 | heat shock transcription factor family protein, contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr2:17388801-17389655 FORWARD | Aliases: HSFB3, T32G6.21, T32G6_21
    AT3G02990AT3G02990.1 Symbol: ATHSFA1E | heat shock factor protein 2 (HSF2) / heat shock transcription factor 2 (HSTF2), identical to heat shock transcription factor 2 (HSF2) SP:Q96320 from (Arabidopsis thaliana); contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr3:673486-676410 FORWARD | Aliases: F13E7.6, F13E7_6, HSFA1E
    AT3G22830AT3G22830.1 Symbol: AT HSFA6B | heat shock transcription factor family protein, contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr3:8078827-8081058 FORWARD | Aliases: HSFA6B, MWI23.20
    AT3G24520AT3G24520.1 Symbol: AT HSFC1 | heat shock transcription factor family protein, contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr3:8941073-8942881 FORWARD | Aliases: HSFC1, MOB24.9
    AT3G51910AT3G51910.1 Symbol: AT HSFA7A | heat shock transcription factor family protein, contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr3:19276272-19277597 FORWARD | Aliases: F4F15.20, HSFA7A
    AT3G63350AT3G63350.1 Symbol: AT HSFA7B | heat shock transcription factor family protein, contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr3:23410443-23411787 FORWARD | Aliases: HSFA7B, MAA21.4
    AT4G11660AT4G11660.1 Symbol: AT HSFB2B | heat shock factor protein 7 (HSF7) / heat shock transcription factor 7 (HSTF7), identical to heat shock factor protein 7 (HSF7) SP:Q9T0D3 from (Arabidopsis thaliana) | chr4:7042627-7044702 FORWARD | Aliases: HSFB2B, T5C23.90, T5C23_90
    AT4G13980AT4G13980.1 Symbol: AT HSFA5 | heat shock transcription factor family protein, contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr4:8076975-8079284 REVERSE | Aliases: DL3030C, FCAALL.27, HSFA5
    AT4G17750AT4G17750.1 Symbol: HSF1 | heat shock factor protein 1 (HSF1) / heat shock transcription factor 1 (HSTF1), identical to heat shock transcription factor 1 (HSF1) SP:P41151 from (Arabidopsis thaliana) ;contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr4:9869831-9871616 REVERSE | Aliases: ARABIDOPSIS HEAT SHOCK FACTOR 1, ATHSF1, ATHSFA1A, DL4910C, FCAALL.107, HEAT SHOCK FACTOR, HSFA1A
    AT4G18870AT4G18870.1 Symbol: None | heat shock transcription factor family protein, contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr4:10346180-10347238 FORWARD | Aliases: F13C5.40, F13C5_40
    AT4G18880AT4G18880.1 Symbol: AT HSFA4A | heat shock transcription factor 21 (HSF21), identical to heat shock transcription factor 21 (Arabidopsis thaliana) GI:3399765; contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr4:10347593-10349573 REVERSE | Aliases: F13C5.50, F13C5_50, HSFA4A
    AT4G36990AT4G36990.1 Symbol: HSF4 | heat shock factor protein 4 (HSF4) / heat shock transcription factor 4 (HSTF4), identical to heat shock transcription factor 4 (HSF4) SP:Q96320 from (Arabidopsis thaliana) | chr4:17440287-17442145 FORWARD | Aliases: AP22.9, AP22_9, AT HSFB1, ATHSF4, HEAT SHOCK FACTOR 4, HEAT SHOCK TRANSCRIPTION FACTOR 4, HSFB1
    AT5G03720AT5G03720.1 Symbol: AT HSFA3 | heat shock transcription factor family protein, contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr5:971912-973682 REVERSE | Aliases: F17C15.140, F17C15_140, HSFA3
    AT5G16820AT5G16820.1 AT5G16820.2 Symbol: HSF3 | heat shock factor protein 3 (HSF3) / heat shock transcription factor 3 (HSTF3), identical to heat shock transcription factor 3 (HSF3) SP:O81821 from (Arabidopsis thaliana) | chr5:5530333-5532813 FORWARD | Aliases: ATHSFA1B, F5E19.160, F5E19_160, HEAT SHOCK FACTOR 3, HSFA1B
    AT5G43840AT5G43840.1 Symbol: AT HSFA6A | heat shock transcription factor family protein, contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr5:17642664-17643591 REVERSE | Aliases: HSFA6A, MQD19.20, MQD19_20
    AT5G45710AT5G45710.1 Symbol: AT HSFA4C | heat shock transcription factor family protein, contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr5:18558079-18560090 FORWARD | Aliases: HSFA4C, MRA19.11, MRA19_11, RHA1
    AT5G54070AT5G54070.1 Symbol: AT HSFA9 | heat shock transcription factor family protein, contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr5:21961209-21962545 FORWARD | Aliases: HSFA9, MJP23.4, MJP23_4
    AT5G62020AT5G62020.1 Symbol: AT HSFB2A | heat shock factor protein, putative (HSF6) / heat shock transcription factor, putative (HTSF6), identical to heat shock transcription factor 6 (HSF6) SP: Q9SCW4 from (Arabidopsis thaliana) ;contains Pfam profile: PF00447 HSF-type DNA-binding domain | chr5:24933315-24934869 FORWARD | Aliases: HSFB2A, MTG10.7, MTG10_7

    HSF Family Introduction

    During the initial stages of heat stress, the heat shock transcription factor (HSF) is the primary molecule responsible for relaying signals of cellular stress to the transcriptional apparatus. Metazoan HSFs comprise a rather small gene family consisting of four distinct types. In vertebrates, HSF1 is considered to be the predominant heat-inducible HSF, while HSF2 responds to the developmental signals and is strongly activated in the erythroleukemia cells by hemin treatment (Sistonen et al., 1992, 1994; Baler et al., 1993; Sarge et al., 1993). Avian species have an additional factor, HSF3, that functions during heat stress and is cell type-specific (Nakai and Morimoto, 1993; Nakai, et al., 1995). In addition to HSFs that activate transcription, HSF4 in man has no capacity to support activated transcription and has been shown to suppress expression of heat shock genes under control conditions (Nakai et al., 1997).

    Based on parsimony analysis of their DNA-binding domains (DBDs) and a comparison of oligomerization domains (ODs), they have been assigned to major classes A and B (Czarnecka-Verner et al., 1995, 1997, ; Nover et al., 1996; Nover and Scharf, 1997; Czarnecka-Verner and Gurley, 1999).These two groups of HSFs appear to be unique to plants with no clear relationships to HSF types in other organisms. Other differences between class A and B HSFs include the relative position of the nuclear localization sequence (NLS), and the presence or absence of a C-terminal hydrophobic region (HR-C), which in vertebrates has been shown to be involved in regulation of the trimerization state of HSF. In addition, the class B HSFs have much shortened C-terminal domains and, with the exception of tomato LpHSFB1 (LpHSF24), seem to lack functional transcriptional activation motifs (AHA or TRP repeats) which are present in class A HSFs.

    Czarnecka-Verner E, Yuan CX, Scharf KD, Englich G, Gurley WB
    Plants contain a novel multi-member class of heat shock factors without transcriptional activator potential.
    Plant Mol Biol. 2000 Jul;43(4):459-71.
    PMID: 11052198

    HSF Family Binding Site

    FamilySubfamily or DomainCis-element nameBinding siteReference
    HSF  R013382 
    HSF  R013383 
    HSF  R013384 
    HSF  R09928 
    HSF  HSETTCnnGAALittlefield, Nat. Struct Biol. 6:464-470 (1999)

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    last updated:2006-07-20