DATF - The Database of Arabidopsis Transcription Factor
Home PlantTFDB Blast Search Download Help ID (eg. AT1G01060)
 

  • AP2-EREBP Family Introduction
  • AP2-EREBP Family Strucutre Information
  • This family has no binding site information!
  • Download Sequences of This Family
          Genomic sequence       cds sequence       protein sequence
  • Multi-alignment and Phylogenetic Tree for DNA binding domain   
         Multi-alignment     Phylogenetic Tree EMF vector Image format     Phylogenetic Tree JPG Image

    • List of AP2-EREBP family(Total: 146 Loci; 159 Gene Models):

    Page: 1 2 3 4 5 list all   (30 Loci a page)
    LocusGene ModelsDescription
    AT1G01250AT1G01250.1 Symbol: None | encodes a member of the DREB subfamily A-4 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 17 members in this subfamily including TINY. | chr1:104491-105324 REVERSE | Aliases: F6F3.6, F6F3_6
    AT1G03800AT1G03800.1 Symbol: ATERF10/ERF10 | encodes a member of the ERF (ethylene response factor) subfamily B-1 of ERF/AP2 transcription factor family (ATERF-10). The protein contains one AP2 domain. There are 15 members in this subfamily including ATERF-3, ATERF-4, ATERF-7, and leafy petiole. | chr1:957260-957997 REVERSE | Aliases: ATERF10, ERF10, F21M11.29, F21M11_29
    AT1G04370AT1G04370.1 Symbol: ATERF14 | encodes a member of the ERF (ethylene response factor) subfamily B-3 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 18 members in this subfamily including ATERF-1, ATERF-2, AND ATERF-5. | chr1:1175176-1175577 FORWARD | Aliases: ATERF14, F19P19.19, F19P19_19
    AT1G06160AT1G06160.1 Symbol: None | encodes a member of the ERF (ethylene response factor) subfamily B-3 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 18 members in this subfamily including ATERF-1, ATERF-2, AND ATERF-5. | chr1:1883003-1883933 FORWARD | Aliases: F9P14.2, F9P14_2
    AT1G12610AT1G12610.1 Symbol: DDF1 | encodes a member of the DREB subfamily A-1 of ERF/AP2 transcription factor family (DDF1). The protein contains one AP2 domain. There are six members in this subfamily, including CBF1, CBF2, and CBF3. Overexpression of this gene results in delayed flowering and dwarfism, reduction of gibberellic acid biosynthesis, and increased tolerance to high levels of salt. This gene is expressed in all tissues examined, but most abundantly expressed in upper stems. Overexpression of this gene is also correlated with increased expression of GA biosynthetic genes and RD29A (a cold and drought responsive gene). | chr1:4289954-4290994 REVERSE | Aliases: DDF1, DWARF AND DELAYED FLOWERING 1, T12C24.14, T12C24_14
    AT1G12630AT1G12630.1 Symbol: None | encodes a member of the DREB subfamily A-4 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 17 members in this subfamily including TINY. | chr1:4298907-4299473 FORWARD | Aliases: T12C24.16, T12C24_16
    AT1G12890AT1G12890.1 Symbol: None | encodes a member of the ERF (ethylene response factor) subfamily B-1 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 15 members in this subfamily including ATERF-3, ATERF-4, ATERF-7, and leafy petiole. | chr1:4391732-4392391 FORWARD | Aliases: F13K23.25
    AT1G12980AT1G12980.1 Symbol: ESR1 | encodes a member of the ERF (ethylene response factor) subfamily B-1 of ERF/AP2 transcription factor family (ESR1). The protein contains one AP2 domain. There are 15 members in this subfamily including ATERF-3, ATERF-4, ATERF-7, and leafy petiole. | chr1:4429716-4430963 FORWARD | Aliases: DORNROSCHEN, DRN, ENHANCER OF SHOOT REGENERATION 1, F3F19.1, F3F19_1
    AT1G13260AT1G13260.1 Symbol: RAV1 | DNA-binding protein RAV1 (RAV1), identical to SP:Q9ZWM9 DNA-binding protein RAV1 {Arabidopsis thaliana}, RAV1 GI:3868857 from (Arabidopsis thaliana) | chr1:4542165-4543739 FORWARD | Aliases: RAV1, T6J4.2, T6J4_2
    AT1G15360AT1G15360.1 Symbol: None | encodes a member of the ERF (ethylene response factor) subfamily B-6 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 12 members in this subfamily including RAP2.11. | chr1:5283536-5284668 FORWARD | Aliases: F9L1.31, F9L1_31
    AT1G16060AT1G16060.1 AT1G16060.2 Symbol: None | ovule development protein, putative, similar to ovule development protein AINTEGUMENTA (GI:1209099)(Arabidopsis thaliana) | chr1:5508537-5511729 FORWARD | Aliases: T24D18.16, T24D18_16
    AT1G19210AT1G19210.1 Symbol: None | encodes a member of the DREB subfamily A-5 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 15 members in this subfamily including RAP2.1, RAP2.9 and RAP2.10. | chr1:6626813-6627521 REVERSE | Aliases: T29M8.8, T29M8_8
    AT1G21910AT1G21910.1 Symbol: None | encodes a member of the DREB subfamily A-5 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 15 members in this subfamily including RAP2.1, RAP2.9 and RAP2.10. | chr1:7696525-7697688 FORWARD | Aliases: T26F17.14, T26F17_14
    AT1G22190AT1G22190.1 Symbol: None | AP2 domain-containing transcription factor, putative, similar to AP2 domain containing protein RAP2.4 GI:2281633 from (Arabidopsis thaliana) | chr1:7835771-7837277 FORWARD | Aliases: F16L1.8, F16L1_8
    AT1G22810AT1G22810.1 Symbol: None | encodes a member of the DREB subfamily A-5 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 16 members in this subfamily including RAP2.1, RAP2.9 and RAP2.10. | chr1:8074040-8075026 REVERSE | Aliases: T22J18.2, T22J18_2
    AT1G22985AT1G22985.1 Symbol: None | encodes a member of the ERF (ethylene response factor) subfamily B-5 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 7 members in this subfamily. | chr1:8135202-8135909 REVERSE | Aliases: None
    AT1G24590AT1G24590.1 Symbol: None | encodes a member of the ERF (ethylene response factor) subfamily B-1 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 15 members in this subfamily including ATERF-3, ATERF-4, ATERF-7, and leafy petiole. | chr1:8714375-8715295 REVERSE | Aliases: F21J9.25
    AT1G25470AT1G25470.1 AT1G25470.2 Symbol: None | encodes a member of the ERF (ethylene response factor) subfamily B-6 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 12 members in this subfamily including RAP2.11. | chr1:8944596-8946601 REVERSE | Aliases: F2J7.8, F2J7_8
    AT1G25560AT1G25560.1 Symbol: None | AP2 domain-containing transcription factor, putative, similar to DNA-binding protein RAV2 GI:3868859 from (Arabidopsis thaliana) | chr1:8981664-8983028 REVERSE | Aliases: F2J7.3, F2J7_3
    AT1G28160AT1G28160.1 Symbol: None | encodes a member of the ERF (ethylene response factor) subfamily B-1 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 15 members in this subfamily including ATERF-3, ATERF-4, ATERF-7, and leafy petiole. | chr1:9839374-9840111 FORWARD | Aliases: F3H9.18, F3H9_18
    AT1G28360AT1G28360.1 Symbol: ATERF12/ERF12 | encodes a member of the ERF (ethylene response factor) subfamily B-1 of ERF/AP2 transcription factor family (ERF12). The protein contains one AP2 domain. There are 15 members in this subfamily including ATERF-3, ATERF-4, ATERF-7, and leafy petiole. | chr1:9951835-9952726 FORWARD | Aliases: ATERF12, ERF12, F3M18.21, F3M18_21
    AT1G28370AT1G28370.1 Symbol: ATERF11/ERF11 | encodes a member of the ERF (ethylene response factor) subfamily B-1 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 15 members in this subfamily including ATERF-3, ATERF-4, ATERF-7, and leafy petiole. | chr1:9955955-9956926 REVERSE | Aliases: ATERF11, ERF11, F3M18.20, F3M18_20
    AT1G33760AT1G33760.1 Symbol: None | encodes a member of the DREB subfamily A-4 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 17 members in this subfamily including TINY. | chr1:12237858-12238478 FORWARD | Aliases: F14M2.12, F14M2_12
    AT1G36060AT1G36060.1 Symbol: None | encodes a member of the DREB subfamily A-6 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 8 members in this subfamily including RAP2.4. | chr1:13455930-13456906 REVERSE | Aliases: F5J5.5, F5J5_5
    AT1G43160AT1G43160.1 Symbol: RAP2.6 | encodes a member of the ERF (ethylene response factor) subfamily B-4 of ERF/AP2 transcription factor family (RAP2.6). The protein contains one AP2 domain. There are 7 members in this subfamily. | chr1:16266253-16267258 FORWARD | Aliases: F1I21.18, F1I21_18, RAP2.6
    AT1G44830AT1G44830.1 Symbol: None | encodes a member of the DREB subfamily A-5 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 15 members in this subfamily including RAP2.1, RAP2.9 and RAP2.10. | chr1:16936232-16936867 FORWARD | Aliases: T12C22.10, T12C22_10
    AT1G46768AT1G46768.1 Symbol: RAP2.1 | encodes a member of the DREB subfamily A-5 of ERF/AP2 transcription factor family (RAP2.1). The protein contains one AP2 domain. There are 16 members in this subfamily including RAP2.9 and RAP2.10. | chr1:17268141-17268976 REVERSE | Aliases: F2G19.32, F2G19_32, RAP2.1
    AT1G49120AT1G49120.1 Symbol: None | encodes a member of the ERF (ethylene response factor) subfamily B-6 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 12 members in this subfamily including RAP2.11. | chr1:18177095-18178084 FORWARD | Aliases: F27J15.11, F27J15_11
    AT1G50640AT1G50640.1 Symbol: ATERF3/ERF3 | encodes a member of the ERF (ethylene response factor) subfamily B-1 of ERF/AP2 transcription factor family (ATERF-3). The protein contains one AP2 domain. There are 15 members in this subfamily including ATERF-3, ATERF-4, ATERF-7, and leafy petiole. | chr1:18760816-18762101 REVERSE | Aliases: ATERF 3, ATERF3, ERF3, ETHYLENE RESPONSIVE ELEMENT BINDING FACTOR 3, F11F12.4, F11F12_4
    AT1G50680AT1G50680.1 Symbol: None | AP2 domain-containing transcription factor, putative, similar to RAV1 (Arabidopsis thaliana) GI:3868857 | chr1:18781269-18782282 REVERSE | Aliases: F17J6.20, F17J6_20
    Page: 1 2 3 4 5 list all

    AP2-EREBP Family Introduction

    AP2 (APETALA2) and EREBPs (ethylene-responsive element binding proteins) are the prototypic members of a family of transcription factors unique to plants, whose distinguishing characteristic is that they contain the so-called AP2 DNA-binding domain. AP2/ REBP genes form a large multigene family, and they play a variety of roles throughout the plant life cycle: from being key regulators of several developmental processes, like floral organ identity determination or control of leaf epidermal cell identity, to forming part of the mechanisms used by plants to respond to various types of biotic and environmental stress.

    Riechmann JL, Meyerowitz EM.
    The AP2/EREBP family of plant transcription factors.
    Biol Chem. 1998 Jun;379(6):633-46. Review.
    PMID: 9687012 [PubMed - indexed for MEDLINE]


    These proteins contain either one (EREBP subfamily) or two (AP2 subfamily) copies of an approximately 70 amino acid domain termed the AP2 repeat because of its initial description in the floral homeotic protein APETALA2 (AP2). In proteins containing a single AP2 repeat, this region has been shown to exhibit DNA binding activity. Proteins that have a single AP2 repeat include EREBPs/ethylene response factors (ERFs), C-repeat/dehydration response element binding proteins (CBFs/DREBs), ABI4 and TINY. Proteins containing two AP2 repeats include AP2, ANT and the products of the maize indeterminate spikelet1 (ids1) and Glossy15 (Gl15) genes.

    DNA binding specificity has been determined for three types of AP2/EREBP proteins that contain a single AP2 repeat. The first class are proteins which bind to ethylene response elements (ERE) or GCC boxes (tobacco EREBPs, Arabidopsis AtEBP and AtERF1-5, and tomato Pti4-6) found in the promoters of ethylene-inducible pathogenesis related genes .

    The second class includes proteins that bind to the C-repeat or dehydration response element (DRE) in the promoters of genes that are turned on in response to low temperatures and/or water deficit (CBF1, CBF2, CBF3/DREB1A and DREB2A). The C-repeat/DREs contain the core sequence CCGAC (19).

    The third class of AP2/EREBP-like proteins that have been shown to bind DNA consists of Arabidopsis RAV1 and RAV2. RAV1 and RAV2 are highly related proteins that contain two DNA binding motifs: a single AP2 repeat and a B3-like domain Using an in vitro selection procedure, the DNA binding specificity of the two AP2 repeat containing protein ANT was found to be 5'-gCAC(A/G)N(A/T)TcCC(a/g)ANG(c/t)-3'. This consensus site is much longer than sites recognized by proteins containing a single AP2 repeat and neither AP2 repeat of ANT was alone capable of binding to the selected sequences, suggesting that both AP2 repeats make DNA contacts.

    Nole-Wilson S, Krizek BA.
    DNA binding properties of the Arabidopsis floral development protein AINTEGUMENTA.
    Nucleic Acids Res. 2000 Nov 1;28(21):4076-82. Erratum in: Nucleic Acids Res 2001 Mar 1;29(5):1261.
    PMID: 11058102 [PubMed - indexed for MEDLINE]

    © Center for Bioinformatics(CBI), Peking University
    Any Comments and suggestions mail to :
    last updated:2006-07-20